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Cover picture: Coregulation of Kir2.1 channels by PIP2 and long polymines (PA). The channel opens (O) when interacting with PIP2 and closes when this interaction is lost, either transiently (C) or due to PIP2 depletion (rundown, R) or screening by neomycin (CN). PA strengthens the open channel PIP2 interaction (OA) and also causes voltage-dependent block (BA). (see article by XIE et al., 541-549)
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