The Journal of General Physiology
World Precision Insruments
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Cover Figure


Cover picture: Cartoon illustrating the involvement of S4 in voltage sensing and opening of voltage-gated ion channels. S4 segments move independently of each other in the voltage-sensing phase. Opening involves a further motion of the S4 segments, which is highly cooperative and exerts force on the channel's gates (see article by Pathak et al., 57-69)).

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