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The prevailing model for cellular signaling during chemotaxis of sperm from marine invertebrates, in particular sea urchins. Top: molecular components of the signaling pathway. Bottom: sequence of events that cause the entry of Ca ions into the sperm cell. See related article by Solzin, J., A. Helbig, Q. Van, J.E. Brown, E. Hildebrand, I. Weyand, and U.B. Kaupp in this issue, pp. 115-124.
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