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The Journal of General Physiology 120 4 Cover picture:(Top left) ACh-evoked single channel currents recorded at motor endplates from control and patient with congenital myasthenic syndrome ([ACh] 5 1 and 5 mM, respectively). (Bottom left) Single channel currents through engineered acetylcholine receptors with mutations at sites identified in the patient ([ACh] 5 10 mM). Picture shows structural model of the ACh binding domain formed by a (magenta) and ¥ (green) subunits with mutant residues shown in ball and stick representation. See related article by Sine, S.M., X.-M. Shen, H.-L. Wang, K. Ohno, W.-Y. Lee, A. Tsujino, J. Brengmann, N. Bren, J. Vajsar, and A.G. Engel in this issue, pp. 483-496.

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