About the Cover
Cover picture: The M2 domain selectivity filter region of the glycine
receptor channel (GlyR)with mutations that reverse ion selectivity.The anion-selective WT 1 GlyR (top)has a partially hydrated Cl ion closely interacting with the positive arginine residues (R0').
The cation-selective mutant GlyR (with A-1'E and P-2'
;bottom)
has a more hydrated Na ion interacting with negative glutamate residues.
See related articles by Keramidas, A.,
A.J. Moorhouse, K.D. Pierce, P.R.
Schofield,
and P.H.
Barry, in this
issue,
pp.
393-410,
and by
Moorhouse, A.J., A. Keramidas, A. Zaykin,
P.R. Schofield, and P.H.Barry,
in this issue,
pp.
411-425.
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