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The Journal of General Physiology, Vol 98, 869-880, Copyright © 1991 by The Rockefeller University Press
ARTICLES |
JC Parker, GC Colclasure and TJ McManus
Department of Medicine, University of North Carolina, Chapel Hill 27599- 7035.
Hypertonic shrinkage of dog red cells caused rapid activation of Na/H exchange and rapid deactivation of [K-Cl] cotransport. Hypotonic swelling caused delayed deactivation of Na/H exchange and delayed activation of [K-Cl] cotransport. Okadaic acid stimulated shrinkage- induced Na/H exchange and inhibited swelling-induced [K-Cl] cotransport. The data are compatible with the kinetic model of Jennings and Al-Rohil (1990. J. Gen. Physiol. 95:1021-1040) for volume regulation of [K-Cl] cotransport in rabbit red cells and suggest that in dog red cells Na/H exchange and [K-Cl] cotransport are controlled by a common regulatory system. The proposal of Jennings and Schulz (1991. J. Gen. Physiol. 96:799-817) that activation/deactivation of volume- sensitive transport involves phosphorylation/dephosphorylation of a regulatory protein is supported by these observations.
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