The Journal of General Physiology
Cell MicroControls
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The Journal of General Physiology, Vol 83, 133-142, Copyright © 1984 by The Rockefeller University Press

ARTICLES

Analysis of sodium current fluctuations in the cut-open squid giant axon

I Llano and F Bezanilla

Patch pipettes were used to record the current arising from small populations of sodium channels in voltage-clamped cut-open squid axons. The current fluctuations associated with the time-variant sodium conductance were analyzed with nonstationary statistical techniques in order to obtain an estimate for the conductance of a single sodium channel. The results presented support the notion that the open sodium channel in the squid axon has only one value of conductance, 3.5 pS.
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