The Journal of General Physiology
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The Journal of General Physiology, Vol 82, 599-618, Copyright © 1983 by The Rockefeller University Press

ARTICLES

Hydrogen ion block of the sodium pore in squid giant axons

T Begenisich and M Danko

The block of squid axon sodium channels by H ions was studied using voltage-clamp and internal perfusion techniques. An increase in the concentration of internal permeant ions decreased the block produced by external H ions. The voltage dependence of the block was found to be nonmonotonic: it was reduced by both large positive and large negative potentials. The ability of internal ions to modify the block by external H+ is explained by a competition among these ions for a binding site within the pore. The nonmonotonic voltage dependence is consistent with this picture if the hydrogen ions are allowed to be permeant.
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