|
|
|
|
|
|
|
||
The Journal of General Physiology, Vol 67, 621-638, Copyright © 1976 by The Rockefeller University Press
ARTICLES |
S Hagiwara, S Miyazaki and NP Rosenthal
The kinetics of the membrane current during the anomalous or inward- going rectification of the K current in the egg cell membrane of the starfish Mediaster aequalis were analyzed by voltage clamp. The rectification has instantaneous and time-dependent components. The time- dependent increase in the K conductance for the negative voltage pulse as well as the decrease in the conductance for the positive pulse follows first-order kinetics. The steady-state conductance increases as the membrane potential becomes more negative and reaches the saturation value at about -40 mV more negative than the K equilibrium potential, V(K). The entire K conductance can be expressed by g(K).n; g g(K) represents the component for the time-independent conductance which depends on V-V(K) and [K+]o, and n is a dimensionless number (1 is greater than or equal to n is greater than or equal to 0) and determined by two rate constants which depend only on V-V(K). Cs+ does not carry any significant current through the K channel but blocks the channel at low concentration in the external medium. The blocking effect increases as the membrane potential is made more negative and the potential-dependent blocking by the external Cs+ also has instantaneous and time-dependent components.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  B. Rosati, M. Dong, L. Cheng, S.-R. Liou, Q. Yan, J. Y. Park, E. Shiang, M. Sanguinetti, H.-S. Wang, and D. McKinnon Evolution of ventricular myocyte electrophysiology Physiol Genomics, November 1, 2008; 35(3): 262 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Su, Y. Ohno, C. Lossin, H. Hibino, A. Inanobe, and Y. Kurachi Inhibition of Astroglial Inwardly Rectifying Kir4.1 Channels by a Tricyclic Antidepressant, Nortriptyline J. Pharmacol. Exp. Ther., February 1, 2007; 320(2): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Irie, I. Fukui, and H. Ohmori Activation of GIRK Channels by Muscarinic Receptors and Group II Metabotropic Glutamate Receptors Suppresses Golgi Cell Activity in the Cochlear Nucleus of Mice J Neurophysiol, November 1, 2006; 96(5): 2633 - 2644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Zampini, P. Valli, G. Zucca, and S. Masetto Single-Channel L-Type Ca2+ Currents in Chicken Embryo Semicircular Canal Type I and Type II Hair Cells J Neurophysiol, August 1, 2006; 96(2): 602 - 612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kristensen, T. Hansen, and C. Juel Membrane proteins involved in potassium shifts during muscle activity and fatigue Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R766 - R772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Panama and A. N. Lopatin Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels J. Physiol., March 1, 2006; 571(2): 287 - 302. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Christophe, N. Doerflinger, D. J. Lavery, Z. Molnar, S. Charpak, and E. Audinat Two Populations of Layer V Pyramidal Cells of the Mouse Neocortex: Development and Sensitivity to Anesthetics J Neurophysiol, November 1, 2005; 94(5): 3357 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-G. Shin, Y. Xu, and Z. Lu Evidence for Sequential Ion-binding Loci along the Inner Pore of the IRK1 Inward-rectifier K+ Channel J. Gen. Physiol., July 25, 2005; 126(2): 123 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-G. Shin and Z. Lu Mechanism of the Voltage Sensitivity of IRK1 Inward-rectifier K+ Channel Block by the Polyamine Spermine J. Gen. Physiol., March 28, 2005; 125(4): 413 - 426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ishihara and T. Ehara Two modes of polyamine block regulating the cardiac inward rectifier K+ current IK1 as revealed by a study of the Kir2.1 channel expressed in a human cell line J. Physiol., April 1, 2004; 556(1): 61 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Guo and Z. Lu Interaction Mechanisms between Polyamines and IRK1 Inward Rectifier K+ Channels J. Gen. Physiol., October 27, 2003; 122(5): 485 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. DiFrancesco If inhibition: a novel mechanism of action Eur. Heart J. Suppl., September 1, 2003; 5(suppl_G): G19 - G25. [Abstract] [PDF]
|
|
|
|
 |
|
 D. Yang, D. K. MacCallum, S. A. Ernst, and B. A. Hughes Expression of the Inwardly Rectifying K+ Channel Kir2.1 in Native Bovine Corneal Endothelial Cells Invest. Ophthalmol. Vis. Sci., August 1, 2003; 44(8): 3511 - 3519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.-Q. Mao, P. R. MacLeish, and J. D. Victor Role of Hyperpolarization-Activated Currents for the Intrinsic Dynamics of Isolated Retinal Neurons Biophys. J., April 1, 2003; 84(4): 2756 - 2767. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Guo, Y. Ramu, A. M. Klem, and Z. Lu Mechanism of Rectification in Inward-rectifier K+ Channels J. Gen. Physiol., March 31, 2003; 121(4): 261 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Hommers, M. J. Lohse, and M. Bunemann Regulation of the Inward Rectifying Properties of G-protein-activated Inwardly Rectifying K+ (GIRK) Channels by Gbeta gamma Subunits J. Biol. Chem., January 3, 2003; 278(2): 1037 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ji, A. M. F. Salapatek, and N. E. Diamant Inwardly rectifying K+ channels in esophageal smooth muscle Am J Physiol Gastrointest Liver Physiol, November 1, 2000; 279(5): G951 - G960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Dickson, J. Magistretti, M. H. Shalinsky, E. Fransen, M. E. Hasselmo, and A. Alonso Properties and Role of Ih in the Pacing of Subthreshold Oscillations in Entorhinal Cortex Layer II Neurons J Neurophysiol, May 1, 2000; 83(5): 2562 - 2579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Lu, Y.-g. Zhu, and J. Yang Cytoplasmic amino and carboxyl domains form a wide intracellular vestibule in an inwardly rectifying potassium channel PNAS, August 17, 1999; 96(17): 9926 - 9931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wessel, W. B. Kristan Jr, and D. Kleinfeld Supralinear Summation of Synaptic Inputs by an Invertebrate Neuron: Dendritic Gain Is Mediated by an "Inward Rectifier" K+ Current J. Neurosci., July 15, 1999; 19(14): 5875 - 5888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-C. Shieh, J.-C. Chang, and C.-C. Kuo K+ Binding Sites and Interactions between Permeating K+ Ions at the External Pore Mouth of an Inward Rectifier K+ Channel (Kir2.1) J. Biol. Chem., June 18, 1999; 274(25): 17424 - 17430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Golding, M. J. Ferragamo, and D. Oertel Role of Intrinsic Conductances Underlying Responses to Transients in Octopus Cells of the Cochlear Nucleus J. Neurosci., April 15, 1999; 19(8): 2897 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamada, A. Inanobe, and Y. Kurachi G Protein Regulation of Potassium Ion Channels Pharmacol. Rev., December 1, 1998; 50(4): 723 - 757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Bennett and C. J. Wilson Synaptic Regulation of Action Potential Timing in Neostriatal Cholinergic Interneurons J. Neurosci., October 15, 1998; 18(20): 8539 - 8549. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Sim and T.G.J. Allen Morphological and Membrane Properties of Rat Magnocellular Basal Forebrain Neurons Maintained in Culture J Neurophysiol, October 1, 1998; 80(4): 1653 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Rusch, A. Lysakowski, and R. A. Eatock Postnatal Development of Type I and Type II Hair Cells in the Mouse Utricle: Acquisition of Voltage-Gated Conductances and Differentiated Morphology J. Neurosci., September 15, 1998; 18(18): 7487 - 7501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takahashi, Y. Kajikawa, and T. Tsujimoto G-Protein-Coupled Modulation of Presynaptic Calcium Currents and Transmitter Release by a GABAB Receptor J. Neurosci., May 1, 1998; 18(9): 3138 - 3146. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. TAKAHASHI and Y. OKAMURA Ion Channels and Early Development of Neural Cells Physiol Rev, April 1, 1998; 78(2): 307 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Schweitzer, S. G. Madamba, and G. R. Siggins Somatostatin Increases a Voltage-Insensitive K+ Conductance in Rat CA1 Hippocampal Neurons J Neurophysiol, March 1, 1998; 79(3): 1230 - 1238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Brunton and S. Charpak µ-Opioid Peptides Inhibit Thalamic Neurons J. Neurosci., March 1, 1998; 18(5): 1671 - 1678. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. D. Bennett, J. R. Huguenard, and D. A. Prince Adrenoceptor-Mediated Elevation of Ambient GABA Levels Activates Presynaptic GABAB Receptors in Rat Sensorimotor Cortex J Neurophysiol, July 1, 1997; 78(1): 561 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Kubo, T. Miyashita, and K. Kubokawa A Weakly Inward Rectifying Potassium Channel of the Salmon Brain. GLUTAMATE 179IN THE SECOND TRANSMEMBRANE DOMAIN IS INSUFFICIENT FOR STRONG RECTIFICATION J. Biol. Chem., June 28, 1996; 271(26): 15729 - 15735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. S. Navaratnam, L. Escobar, M. Covarrubias, and J. C. Oberholtzer Permeation Properties and Differential Expression across the Auditory Receptor Epithelium of an Inward Rectifier K[IMAGE] Channel Cloned from the Chick Inner Ear J. Biol. Chem., August 18, 1995; 270(33): 19238 - 19245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Gunning Increased numbers of ion channels promoted by an intracellular second messenger Science, January 2, 1987; 235(4784): 80 - 82. [Abstract] [PDF]
|
|
|
|
