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The Journal of General Physiology, Vol 67, 91-112, Copyright © 1976 by The Rockefeller University Press

ARTICLES

Intracellular pH transients in squid giant axons caused by CO2, NH3, and metabolic inhibitors

WF Boron and P De Weer

The intracellular pH (pHi) of squid giant axons has been measured using glass pH microelectrodes. Resting pHi in artificial seawater (ASW) (pH 7.6-7.8) at 23 degrees C was 7.32 +/- 0.02 (7.28 if corrected for liquid junction potential). Exposure of the axon to 5% CO2 at constant external pH caused a sharp decrease in pHi, while the subsequent removal of the gas caused pHi to overshoot its initial value. If the exposure to CO2 was prolonged, two additional effects were noted: (a) during the exposure, the rapid initial fall in pHi was followed by a slow rise, and (b) after the exposure, the overshoot was greatly exaggerated. Application of external NH4Cl caused pHi to rise sharply; return to normal ASW caused pHi to return to a value below its initial one. If the exposure to NH4Cl was prolonged, two additional effects were noted: (a) during the exposure, the rapid initial rise in pHi was followed by a slow fall, and (b) after the exposure, the undershoot was greatly exaggerated. Exposure to several weak acid metabolic inhibitors caused a fall in pHi whose reversibility depended upon length of exposure. Inverting the electrochemical gradient for H+ with 100 mM K- ASW had no effect on pHi changes resulting from short-term exposure to azide. A mathematical model explains the pHi changes caused by NH4Cl on the basis of passive movements of both NH3 and NH4+. The simultaneous passive movements of CO2 and HCO3-cannot explain the results of the CO2 experiments; these data require the postulation of an active proton extrusion and/or sequestration mechanism.
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Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
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Physiol Rev, October 1, 2003; 83(4): 1183 - 1221.
[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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[Abstract] [Full Text] [PDF]

Home page
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The ERK pathway regulates Na+-HCO3- cotransport activity in adult rat cardiomyocytes
Am J Physiol Heart Circ Physiol, November 1, 2002; 283(5): H2102 - H2109.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Bagorda, L. Guerra, F. Di Sole, C. Hemle-Kolb, R. A. Cardone, T. Fanelli, S. J. Reshkin, S. M. Gisler, H. Murer, and V. Casavola
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J. Biol. Chem., June 7, 2002; 277(24): 21480 - 21488.
[Abstract] [Full Text] [PDF]

Home page
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Ischemia alters the electrical activity of pacemaker cells isolated from the rabbit sinoatrial node
Am J Physiol Heart Circ Physiol, June 1, 2002; 282(6): H2284 - H2295.
[Abstract] [Full Text] [PDF]

Home page
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W. Zeiske, H. Meyer, and H. Wieczorek
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J. Exp. Biol., February 15, 2002; 205(4): 463 - 474.
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Home page
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Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R1940 - R1951.
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Home page
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N. Khandoudi, J. Albadine, P. Robert, S. Krief, I. Berrebi-Bertrand, X. Martin, M. O Bevensee, W. F Boron, and A. Bril
Inhibition of the cardiac electrogenic sodium bicarbonate cotransporter reduces ischemic injury
Cardiovasc Res, December 1, 2001; 52(3): 387 - 396.
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Home page
 J. Biol. Chem.Home page
A. Khadilkar, P. Iannuzzi, and J. Orlowski
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J. Biol. Chem., November 16, 2001; 276(47): 43792 - 43800.
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Home page
 Biol. Bull.Home page
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Biol. Bull., October 1, 2001; 201(2): 186 - 192.
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Home page
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Am J Physiol Renal Physiol, September 1, 2001; 281(3): F493 - F502.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
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J Neurophysiol, August 1, 2001; 86(2): 836 - 844.
[Abstract] [Full Text] [PDF]

Home page
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