The Journal of General Physiology
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The Journal of General Physiology, Vol 63, 553-563, Copyright © 1974 by The Rockefeller University Press

ARTICLE

Calcium-Dependent Myosin from Insect Flight Muscles

William Lehman 1, Belinda Bullard 1, and Kathleen Hammond 1

1 From the A. R. C. Unit of Muscle Mechanisms and Insect Physiology, Department of Zoology, Oxford University, Oxford, England.

Dr. Lehman's present address is the Department of Physiology, Boston University School of Medicine, Boston, Massachusetts 02119.

Calcium regulation of the insect actomyosin ATPase is associated with the thin filaments as in vertebrate muscles, and also with the myosin molecule as in mollusks. This dual regulation is demonstrated using combinations of locust thin filaments with rabbit myosin and locust myosin with rabbit actin; in each case the ATPase of the hybrid actomyosin is calcium dependent. The two regulatory systems are synergistic, the calcium dependency of the locust actomyosin ATPase being at least 10 times that of the hybrid actomyosins described above. Likewise Lethocerus myosin also contains regulatory proteins. The ATPase activity of Lethocerus myosin is labile and is stabilized by the presence of rabbit actin. Tropomyosin activates the ATPase of insect actomyosin and the activation occurs irrespective of whether the myosin is calcium dependent or rendered independent of calcium.

Submitted on August 14, 1973


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