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ARTICLE |
The sodium current (INa) that develops after step depolarization of a voltage clamped squid axon is preceded by a transient outward current that is closely associated with the opening of the activation gates of the Na pores. This "gating current" is best seen when permeant ions (Na and K) are replaced by relatively impermeant ones, and when the linear portion of capacitative current is eliminated by adding current from positive steps to that from exactly equal negative ones. During opening of the Na pores gating current is outward, and as the pores close there is an inward tail of current that decays with approximately the same time-course as INa recorded in Na-containing medium. Both outward and inward gating current are unaffected by tetrodotoxin (TTX). Gating current is capacitative in origin, the result of relatively slow reorientation of charged or dipolar molecules in a suddenly altered membrane field. Close association with the Na activation process is clear from the time-course of gating current, and from the fact that three procedures that reversibly block INa also block gating current: internal perfusion with Zn2+, prolonged depolarization of the membrane, and inactivation of INa with a short positive prepulse.
Submitted on February 7, 1974
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|
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|
|
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|
|
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|
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|
|
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|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
R. Marrannes, E. D. Prins, and G. Clincke Influence of Lubeluzole on Voltage-Sensitive Ca++ Channels in Isolated Rat Neurons J. Pharmacol. Exp. Ther., July 1, 1998; 286(1): 201 - 214. [Abstract] [Full Text]
|
|
|
|
|
|
W. F. Hopkins Toxin and Subunit Specificity of Blocking Affinity of Three Peptide Toxins for Heteromultimeric, Voltage-Gated Potassium Channels Expressed in Xenopus Oocytes J. Pharmacol. Exp. Ther., June 1, 1998; 285(3): 1051 - 1060. [Abstract] [Full Text]
|
|
|
|
|
|
M. de Leon, Y. Wang, L. Jones, E. Perez-Reyes, X. Wei, T. W. Soong, T. P. Snutch, and D. T. Yue Essential Ca2+-Binding Motif for Ca2+-Sensitive Inactivation of L-Type Ca2+ Channels Science, December 1, 1995; 270(5241): 1502 - 1506. [Abstract] [PDF]
|
|
|
|
|
|
J. C. McPhee, D. S. Ragsdale, T. Scheuer, and W. A. Catterall A Critical Role for Transmembrane Segment IVS6 of the Sodium Channel [IMAGE] Subunit in Fast Inactivation J. Biol. Chem., May 19, 1995; 270(20): 12025 - 12034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D Sigg, E Stefani, and F Bezanilla Gating current noise produced by elementary transitions in Shaker potassium channels Science, April 22, 1994; 264(5158): 578 - 582. [Abstract] [PDF]
|
|
|
|
|
|
W. Catterall Structure and function of voltage-sensitive ion channels Science, October 7, 1988; 242(4875): 50 - 61. [Abstract] [PDF]
|
|
|
|
 |
|
 J.A. Talvenheimo, M.M. Tamkun, R.P. Hartshorne, D.J. Messner, R.G. Sharkey, M.R.C. Costa, and W.A. Catterall Structure and Functional Reconstitution of the Voltage-sensitive Sodium Channel from Rat Brain Cold Spring Harb Symp Quant Biol, January 1, 1983; 48(0): 155 - 164. [Abstract] [PDF]
|
|
|
|
|
|
D. Adams and P. Gage Gating currents associated with sodium and calcium currents in an Aplysia neuron Science, May 21, 1976; 192(4241): 783 - 784. [Abstract] [PDF]
|
|
|
|
|
|
F. Bezanilla and C. M. Armstrong Properties of the Sodium Channel Gating Current Cold Spring Harb Symp Quant Biol, January 1, 1976; 40(0): 297 - 304. [Abstract] [PDF]
|
|
|
|
|
|
E. Rojas Gating Mechanism for the Activation of the Sodium Conductance in Nerve Membranes Cold Spring Harb Symp Quant Biol, January 1, 1976; 40(0): 305 - 320. [Abstract] [PDF]
|
|
|
|
