The Journal of General Physiology
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The Journal of General Physiology, Vol 62, 489-507, Copyright © 1973 by The Rockefeller University Press

ARTICLE

Measurement of the Permeability of Biological Membranes Application to the glomerular wall

A. Verniory 1, R. Du Bois 1, P. Decoodt 1, J. P. Gassee 1, and P. P. Lambert 1

1 From the Laboratory for Experimental Medicine, Brussels University and Queen Elisabeth Medical Foundation, Brugmann Hospital, Brussels, Belgium

The transport equation describing the flow of solute across a membrane has been modified on the basis of theoretical studies calculating the drag of a sphere moving in a viscous liquid undergoing Poiseuille flow inside a cylinder. It is shown that different frictional resistance terms should be introduced to calculate the contributions of diffusion and convection. New sieving equations are derived to calculate r and Ap/Deltax (respectively, the pore radius and the total area of the pores per unit of path length). These equations provide a better agreement than the older formulas between the calculated and the experimental glomerular sieving coefficients for [125I]polyvinylpyrrolidone (PVP) fractions with a mean equivalent radius between 19 and 37 Å. From r and Ap/Deltax, the mean effective glomerular filtration pressure has been calculated, applying Poiseuille's law. A value of 15.4 mm Hg has been derived from the mean sieving curve obtained from 23 experiments performed on normal anesthetized dogs.

Submitted on March 9, 1973


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