The Journal of General Physiology
Axon Instruments microelectrode amplifiers
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 901K)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Steinbach, J. H.
Right arrow Articles by Heinemann, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Steinbach, J. H.
Right arrow Articles by Heinemann, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of General Physiology, Vol 62, 255-270, Copyright © 1973 by The Rockefeller University Press

ARTICLE

Nerve-Muscle Interaction In Vitro

Role of acetylcholine



J. H. Steinbach 1, A.J. Harris 1, J. Patrick 1, D. Schubert 1, and S. Heinemann 1

1 From the Neurobiology Department, The Salk Institute, San Diego, California 92112.

Dr. Harris's present address is the Department of Physiology, University of Otago, Dunedin, New Zealand,

Nerve and muscle cells from clonal lines interact in vitro, resulting in the association on the muscle surface of an area of increased acetylcholine sensitivity with a site of nerve-muscle contact. This localization of acetylcholine sensitivity on the muscle cell to a site of contact between nerve and muscle was found to occur when acetylcholine receptors on the muscle had been blocked with alpha-neurotoxin. Localization was also found to occur when the nerve cell had been prevented from releasing acetylcholine. It is concluded that neither the presence of active acetylcholine receptors on the muscle, nor the release of acetylcholine from the nerve, was required for the events leading to the localization of acetylcholine sensitivity in vitro.

Submitted on March 8, 1973


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
P. Elsner, B. Quistorff, T. S. Hermann, J. Dich, and N. Grunnet
Regulation of glycogen accumulation in L6 myotubes cultured under optimized differentiation conditions
Am J Physiol Endocrinol Metab, December 1, 1998; 275(6): E925 - E933.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. Christian, P. Nelson, J Peacock, and M Nirenberg
Synapse formation between two clonal cell lines
Science, May 27, 1977; 196(4293): 995 - 998.
[Abstract] [PDF]

Home page
 ScienceHome page
A Bekoff and W. Betz
Acetylcholine hot spots: development on myotubes cultured from aneural limb buds
Science, September 3, 1976; 193(4256): 915 - 917.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J. P. Brookes, D. K. Berg, and Z. W. Hall
The Biochemical Properties and Regulation of Acetylcholine Receptors in Normal and Denervated Muscle
Cold Spring Harb Symp Quant Biol, January 1, 1976; 40(0): 253 - 262.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
Y. Kidokoro, S. Heinemann, D. Schubert, B. L. Brandt, and F. G. Klier
Synapse Formation and Neurotrophic Effects on Muscle Cell Lines
Cold Spring Harb Symp Quant Biol, January 1, 1976; 40(0): 373 - 388.
[Abstract] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents