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The Journal of General Physiology, Vol 61, 385-399, Copyright © 1973 by The Rockefeller University Press

ARTICLE

Rapid Changes of Potassium Concentration at the Outer Surface of Exposed Single Neurons during Membrane Current Flow

E. Neher 1 and H. D. Lux 1

1 From the Max-Planck-Institute for Psychiatry, Munich, West Germany.

Dr. Neher's present address is Max-Planck-Institut für Biophysikalische Chemie, Göttingen-Nikolausberg, West Germany.

K+-sensitive liquid ion-exchanger microelectrodes are shown to be capable of measuring concentration changes which occur on a millisecond time scale. However, some quaternary ammonium ions, such as tetraethylammonium and acetylcholine, are able to block electrode function when present in concentrations as low as 10-4 to 10-3 M. Changes in extracellular potassium concentration caused by spike activity or voltage clamp pulses of exposed single neurons of the snail Helix pomatia may be measured by these electrodes. Quantitative analysis shows that the total amount of excess potassium found in the vicinity of the cell a short time after a clamp pulse, is in relatively good agreement with the amount of potassium carried by the membrane current.

Submitted on September 7, 1972


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