The Journal of General Physiology
World Precision Insruments
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 1328K)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gunn, R. B.
Right arrow Articles by Wieth, J. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gunn, R. B.
Right arrow Articles by Wieth, J. O.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of General Physiology, Vol 61, 185-206, Copyright © 1973 by The Rockefeller University Press

ARTICLE

Characteristics of Chloride Transport in Human Red Blood Cells

Robert B. Gunn 1, Mads Dalmark 1, D. C. Tosteson 1, and J. O. Wieth 1

1 From the Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710 and the Department of Biophysics, University of Copenhagen, Copenhagen, Denmark

The efflux of chloride-36 from human erythrocytes under steady-state conditions is a saturable process that is competitively inhibited by bicarbonate and noncompetitively inhibited by acetate. This chloride self-exchange flux is reversibly dependent on the pH of the medium between 5.7 and 9.6 with a maximum flux at pH 7.8. The increase in chloride flux between pH 5.7 and 7.8 is inexplicable by the fixed charge hypothesis. The interpretations are made that chloride transport in human erythrocytes is carrier mediated, that bicarbonate utilizes the same transport mechanism, and that the mechanism can be titrated with hydrogen ions into less functional forms for chloride transport.

Submitted on August 19, 1972


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 JGPHome page
M. L. Jennings and J. Cui
Chloride Homeostasis in Saccharomyces cerevisiae: High Affinity Influx, V-ATPase-dependent Sequestration, and Identification of a Candidate Cl- Sensor
J. Gen. Physiol., March 31, 2008; 131(4): 379 - 391.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
V. L. Lew and R. M. Bookchin
Ion Transport Pathology in the Mechanism of Sickle Cell Dehydration
Physiol Rev, January 1, 2005; 85(1): 179 - 200.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
A.K. Stewart, M.N. Chernova, B.E. Shmukler, S. Wilhelm, and S.L. Alper
Regulation of AE2-mediated Cl- Transport by Intracellular or by Extracellular pH Requires Highly Conserved Amino Acid Residues of the AE2 NH2-terminal Cytoplasmic Domain
J. Gen. Physiol., October 29, 2002; 120(5): 707 - 722.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. L. Jennings and M. F. Adame
Direct estimate of 1:1 stoichiometry of K+-Cl{-} cotransport in rabbit erythrocytes
Am J Physiol Cell Physiol, September 1, 2001; 281(3): C825 - C832.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. T. Timmer and R. B. Gunn
Inducible expression of erythrocyte band 3 protein
Am J Physiol Cell Physiol, January 1, 1999; 276(1): C66 - C75.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Pucéat, I. Korichneva, R. Cassoly, and G. Vassort
Identification of Band 3-like Proteins and Cl[IMAGE]/HCO(3)[IMAGE] Exchange in Isolated Cardiomyocytes
J. Biol. Chem., January 20, 1995; 270(3): 1315 - 1322.
[Abstract] [Full Text] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents