The Journal of General Physiology
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The Journal of General Physiology, Vol 60, 72-85, Copyright © 1972 by The Rockefeller University Press

ARTICLE

Ion Transport Through Excitability-Inducing Material (EIM) Channels in Lipid Bilayer Membranes

Ramon Latorre 1, Gerald Ehrenstein 1, and Harold Lecar 1

1 From the Laboratory of Biophysics, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland 20014

Two different methods were used to determine the relative permeability and the voltage-dependent conductance of several different cations in excitability-inducing material (EIM)-doped lipid bilayers. In one method, the conductances of individual channels were measured for Li, Na, K, Cs, NH4, and Ca, and in the other method biionic potentials of a membrane with many channels were measured for Li, Na, K, Cs, and Rb. The experimental results for the two methods are in agreement. The relative permeabilities are proportional to the ionic mobilities in free aqueous solution. The voltage dependence of the conductance is the same for all cations measured.

Submitted on December 30, 1971


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