The Journal of General Physiology
CrossRef
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF, 606K)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bloomquist, E.
Right arrow Articles by Curtis, B. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bloomquist, E.
Right arrow Articles by Curtis, B. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of General Physiology, Vol 59, 476-485, Copyright © 1972 by The Rockefeller University Press

ARTICLE

The Action of Serotonin on Calcium-45 Efflux from the Anterior Byssal Retractor Muscle of Mytilus edulis

Eunice Bloomquist 1 and Brian A. Curtis 1

1 From the Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111

45Ca efflux was studied in resting anterior byssal retractor muscle. The data are described by a three-compartment system. The most rapidly exchanging compartment, with an average time constant of 7 min, contains about 0.9 mM Ca/liter muscle, and probably represents extracellular space. A second compartment, with a time constant of 83 ± 5 min, contains 1.2 mM Ca/liter, and may represent a membrane calcium store. The presence of a third, or more, compartments, probably representing sarcoplasmic reticulum and contractile proteins, is indicated by the fact that the final time constant is 10 times the 83 min time constant of the second compartment. Serotonin (5HT), on initial application, increases 45Ca efflux from this third compartment(s). This effect has a typical dose-response relationship with a maximum response appearing at 10-7 M5HT. In addition, removal of 5HT causes a secondary increase in 45Ca efflux which has a maximum at a 5HT concentration of 10-7 M and declines at both higher and lower doses.

Submitted on July 23, 1971


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Biol. Bull.Home page
C. L. Devlin
5-Hydroxytryptamine Stimulates Net Ca2+ Flux in the Ventricular Muscle of a Mollusc (Busycon canaliculatum) During Cardioexcitation
Biol. Bull., June 1, 2001; 200(3): 344 - 350.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
B. M. Twarog and Y. Muneoka
Calcium and the Control of Contraction and Relaxation in a Molluscan Catch Muscle
Cold Spring Harb Symp Quant Biol, January 1, 1973; 37(0): 489 - 503.
[Abstract] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents