The Journal of General Physiology
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The Journal of General Physiology, Vol 46, 971-981, Copyright © 1963 by The Rockefeller University Press

ARTICLE

Studies of the Origin of Bacterial Viruses

VII. The effect of various mutagens (urethane, ethyl urethane, hydrogen peroxide, desoxycholate, maleic hydrazide, butadiene dioxide, triethylene melamine, versene, and acriflavine) on the proportion of virus-producing and streptomycin-resistant cells in cultures of B. megatherium 20 delta



John H. Northrop 1 and with the technical assistance of Marie King

1 From the Laboratory of The Rockefeller Institute, the Donner Laboratory of Biophysics and Medical Physics, and the Department of Bacteriology, University of California, Berkeley

The mutagens, urethane, ethyl urethane, hydrogen peroxide, desoxycholate, versene, maleic hydrazide, butadiene dioxide, and triethylene melamine, all increase the proportion of virus-producing cells and streptomycin-resistant cells in B. megatherium 20delta cultures to about the same extent. Acriflavine has no effect on the proportion of either type of cell. Triethylene melamine appears to cause mutations to occur without cell division.

Submitted on December 13, 1962


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