¹ From the Wilmer Institute, The Johns Hopkins University and Hospital, Baltimore.

Dr. Edwards' present address is Department of Physiology, University of Utah College of Medicine, Salt Lake City. Dr. Hagiwara's present address is Department of Physiology, Tokyo Medical and Dental University, Tokyo.

The effect of the absence of potassium in the bathing solution on the synaptic inhibitory potentials of the crayfish stretch receptor has been studied.

The inhibitory potentials were increased in size, i.e. became more hyperpolarizing, in the absence of potassium. Since the resting potential of the cell is increased in the absence of potassium, the alteration of the inhibitory potentials implies that the potassium conductance of the membrane is increased. While other ions, e.g. Cl^-, may also be involved, it seems that the membrane potential during inhibition is mainly dominated by K⁺.

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