The Journal of General Physiology
Track the topics, authors and articles important to you
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow PDF (Full Text)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JGP
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gilbert, D. L.
Right arrow Articles by Price, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gilbert, D. L.
Right arrow Articles by Price, W. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of General Physiology, Vol 41, 989-1003, Copyright © 1958 by The Rockefeller University Press

ARTICLE

THE PRODUCTION OF HYDROGEN PEROXIDE BY HIGH OXYGEN PRESSURES

Daniel L. Gilbert 1, Rebeca Gerschman 1, K. Barclay Ruhm 1, and William E. Price 1

1 From the Department of Physiology, The University of Rochester, School of Medicine and Dentistry, Rochester, New York

Hydrogen peroxide is formed in solutions of glutathione exposed to oxygen. This hydrogen peroxide or its precursors will decrease the viscosity of polymers like desoxyribonucleic acid and sodium alginate. Further knowledge of the mechanism of these chemical effects of oxygen might further the understanding of the biological effects of oxygen. This study deals with the rate of solution of oxygen and with the decomposition of hydrogen peroxide in chemical systems exposed to high oxygen pressures. At 6 atmospheres, the absorption coefficient for oxygen into water was about 1 cm./hour and at 143 atmospheres, it was about 2 cm./hour; the difference probably being due to the modus operandi. The addition of cobalt (II), manganese (II), nickel (II), or zinc ions in glutathione (GSH) solutions exposed to high oxygen pressure decreased the net formation of hydrogen peroxide and also the reduced glutathione remaining in the solution. Studies on hydrogen peroxide decomposition indicated that these ions act probably by accelerating the hydrogen perioxide oxidation of glutathione. The chelating agent, ethylenediaminetetraacetic acid disodium salt, inhibited the oxidation of GSH exposed to high oxygen pressure for 14 hours. However, indication that oxidation still occurred, though at a much slower rate, was found in experiments lasting 10 weeks. Thiourea decomposed hydrogen peroxide very rapidly. When GSH solutions were exposed to high oxygen pressure, there was oxidation of the GSH, which became relatively smaller with increasing concentrations of GSH.

Submitted on October 28, 1957


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Arch OphthalmolHome page
B. SCHWARTZ
Initial Studies of the Use of an Open System for the Culture of the Rabbit Lens: Part IV
Arch Ophthalmol, April 1, 1960; 63(4): 643 - 659.
[Abstract] [PDF]


  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents