The Journal of General Physiology
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The Journal of General Physiology, Vol 32, 301-311, Copyright © 1949 by The Rockefeller University Press

ARTICLE

PHAGE FORMATION IN STAPHYLOCOCCUS MUSCAE CULTURES

IV. THE EFFECT OF THE YEAST FRACTION ON VIRUS SYNTHESIS



Winston H. Price 1

1 From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, New Jersey

1. A non-dialyzable fraction from fresh bakers' yeast stimulates the formation of S. muscae virus in cells in synthetic medium in the log phase of multiplication.

2. A similar fraction was not found in calf thymus, pancreas, or liver.

3. The active substance in this fraction has been partially purified.

4. This substance is taken up by the cells. In the absence of virus the added substance is metabolized to a form no longer available for virus formation.

5. A purified yeast fraction, which stimulates adaptive enzyme formation in yeast, has been found to stimulate virus formation in the S. muscae system.

6. The similarities between the yeast fraction that stimulates adaptive enzyme formation and the yeast fraction that stimulates virus formation are discussed.

Submitted on September 22, 1948


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