The Journal of General Physiology
Axon Instruments microelectrode amplifiers
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The Journal of General Physiology, Vol 17, 399-408, Copyright © 1934 by The Rockefeller University Press

ARTICLE

THE EQUILIBRIA BETWEEN NATIVE AND DENATURED HEMOGLOBIN IN SALICYLATE SOLUTIONS AND THE THEORETICAL CONSEQUENCES OF THE EQUILIBRIUM BETWEEN NATIVE AND DENATURED PROTEIN

M. L. Anson 1 and A. E. Mirsky 1

1 From the Laboratories of The Rockefeller Institute for Medical Research, Princeton, N. J., and the Hospital of The Rockefeller Institute for Medical Research, New York

The denaturation of hemoglobin by salicylate in neutral solution is completely reversible.

There is a mobile equilibrium between native and denatured hemoglobin in neutral salicylate solution. The higher the salicylate concentration the greater is the percentage denaturation.

When there is a mobile equilibrium between the native and denatured forms of a protein, denaturation is caused by the addition of any substance which has a greater affinity for the denatured than for the native form.

Theoretically the heat of denaturation must vary with the denaturing agent and must depend on the heat of combination of the denaturing agent with the protein.

Accepted on October 5, 1933


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