¹ From the Laboratory of General Physiology, Harvard University, Cambridge

The intraperitoneal injection of standard young rats of race A with 2/5 cc. of adrenalin chloride 1:50,000 results in increased speed of geotropically oriented creeping upon an inclined surface. It was expected that the effect of such increased frequency of stepping must be analogous to that due to imposition of added loads carried by the rats during geotropic progression. This is verified. The curve connecting with log sin is distorted, under adrenalin, so as to be comparable to that obtained with an added mass of approximately 2.5 gm. upon the young rat's saddle; the threshold slope of surface for orientation is accordingly lowered, from = 20° to = 12.5°; at the new threshold slope of surface the mean orientation angle is the same as in the absence of adrenalin at the corresponding threshold slope of surface.

The total variation of performance is significantly increased in the injected rats, and at given slope of surface the variation is slightly increased. The proportionate modifiable variation of response is quite unaffected by the distortion of the – curve, and is the same as in standard young A rats untreated or carrying additional loads.

It is pointed out that for the consideration of the problem as to whether a given experimental treatment, or a given natural situation, affects in any way the variation of performance of a living system, it is necessary to obtain indices of variability which involve the expression of variation of performance as a function of measured conditions governing the performance.

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