The Journal of General Physiology
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The Journal of General Physiology, Vol 14, 611-616, Copyright © 1931 by The Rockefeller University Press

ARTICLE

THE PRODUCTION AND INHIBITION OF ACTION CURRENTS BY ALCOHOL

W. J. V. Osterhout 1 and S. E. Hill 1

1 From the Laboratories of The Rockefeller Institute for Medical Research

Suitable concentrations of ethyl alcohol (1 to 1.5 M) applied to a spot on a cell of Nitella lower the P.D. enough to cause action currents. The alcohol then suppresses action currents arriving from other parts of the cell and acts as a block. After the alcohol is removed the normal P.D. and irritability return.

Similar experiments on the sciatic nerve and skin of the frog produced only a negative result.

Accepted on April 8, 1931


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