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Published online December 31, 2007
doi:10.1085/jgp.200709849
The Journal of General Physiology, Vol. 131, No. 1, 77-85
The Rockefeller University Press, 0022-1295 $30.00
© 2007 Nagle et al.
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ARTICLE

 Theory of Passive Permeability through Lipid Bilayers



John F. Nagle1,3, John C. Mathai2, Mark L. Zeidel2, and Stephanie Tristram-Nagle1

1 Biological Physics Group, Department of Physics, and 3 Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213
2 Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Cambridge, MA 02139

Correspondence to John F. Nagle: nagle{at}cmu.edu

Recently measured water permeability through bilayers of different lipids is most strongly correlated with the area per lipid A rather than with other structural quantities such as the thickness. This paper presents a simple three-layer theory that incorporates the area dependence in a physically realistic way and also includes the thickness as a secondary modulating parameter. The theory also includes the well-known strong correlation of permeability upon the partition coefficients of general solutes in hydrocarbon environments (Overton's rule). Two mathematical treatments of the theory are given; one model uses discrete chemical kinetics and one model uses the Nernst-Planck continuum equation. The theory is fit to the recent experiments on water permeability in the accompanying paper.

Abbreviations used in this paper: PC, phosphatidylcholine; SD, solubility-diffusion.


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Related Article

Structural Determinants of Water Permeability through the Lipid Membrane
John C. Mathai, Stephanie Tristram-Nagle, John F. Nagle, and Mark L. Zeidel
J. Gen. Physiol. 2007 131: 69-76. [Abstract] [Full Text] [PDF]





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