The Journal of General Physiology
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Published online July 30, 2007
doi:10.1085/jgp.200709817
The Journal of General Physiology, Vol. 130, No. 2, 217-221
The Rockefeller University Press, 0022-1295 $30.00
© 2007 Tseng et al.
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 Cytoplasmic ATP Inhibition of CLC-1 Is Enhanced by Low pH



Pang-Yen Tseng1, Brett Bennetts2, and Tsung-Yu Chen1

1 Center for Neuroscience and Department of Neurology, University of California, Davis, CA 95616
2 St. Vincent's Institute, Fitzroy, Victoria 3065, Australia

Correspondence to Tsung-Yu Chen: tycchen{at}ucdavis.edu

The CLC-1 Cl– channel is abundantly expressed on the plasma membrane of muscle cells, and the membrane potential of muscle cells is largely controlled by the activity of this Cl– channel. Previous studies showed that low intracellular pH increases the overall open probability of recombinant CLC-1 channels in various expression systems. Low intracellular pH, however, is known to inhibit the Cl– conductance on the native muscle membrane, contradicting the findings from the recombinant CLC-1 channels in expressed systems. Here we show that in the presence of physiological concentrations of ATP, reduction of the intracellular pH indeed inhibits the expressed CLC-1, mostly by decreasing the open probability of the common gate of the channel.


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